“Percutaneous Collagen Induction” (PCI) or “Collagen Induction Therapy” (CIT) is a skin treatment in which the outer layers of the skin, epidermis and dermis, are punctured in a minimally invasive manner, activating the body's own repair process and the renewal of damaged skin tissue by increasing collagen production. With the CIT, the wound healing mechanisms are activated without damaging the epidermis; the puncture channels close again quickly.
Needle penetrates skin (Micro needle ø 0.1 mm) - Release of thrombocytes & erythrocytes - Spontaneous Reaction - Release of growth signals & factors
Pricking channels retract from 0.10 to 0.03 mm and less - Invasion of erythrocytes and leucocytes
Fibroblasts join the invasion of erythrocytes and leucocytes. Synthesis of: Elastin Glycosaminoglycans Proteoglycans Collagen III
New matrix components bolster up dermis from inside towards Surface and close pricking channels - Tissue modulation
1. Vascular Reaction 2. Blood Coagulation 3. Inflammation 4. New tissue formation 5. Epithelisation 6. Contraction The change of scarring starts after the end of the contraction and take up to 12 months.
Neocollagenesis - Collageninductiontherapy (CIT) Neo = new Collagen = collagen Genesis = generating/developing Fibroblast cells differentiate to produce Collagen, Elastin and GAG’s. Myofibroblasts contract to add to the tightening effect.
Unlike most cases when tissues are injured, micro-needling does not cause fibroblasts to differentiate rapidly into myofibroblasts (myofibroblasts generate large contractions and actively produce extracellular matrix (ECM) proteins to facilitate wound closure)
Angiogenesis Angio = vessel Genesis = generating / developing Angiogenesis is the physiological process through which new blood vessels form, out of pre-existing vessels. For example: stretch marks
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