Step 1
Needle penetrates skin (Micro needle ø 0.1 mm)
- Release of thrombocytes & erythrocytes
- Spontaneous Reaction
- Release of growth signals & factors
Step 2
- Invasion of erythrocytes and leucocytes
Step 3
Fibroblasts join the invasion of erythrocytes and leucocytes.
Synthesis of:
Elastin
Glycosaminoglycans
Proteoglycans
Collagen III
Step 4
- Tissue modulation
1. Vascular Reaction
2. Blood Coagulation
3. Inflammation
4. New tissue formation
5. Epithelisation
6. Contraction
The change of scarring starts after the end of the contraction and take up to 12 months.
Rapid normalization of cell-to-cell communication (signaling) to improve cell function:
Neocollagenesis - Collageninductiontherapy (CIT)
Neo = new
Collagen = collagen
Genesis = generating/developing
Using atraumatic needles enables the skin to seal very fast
Unlike most cases when tissues are injured, micro-needling does not cause fibroblasts to differentiate rapidly into myofibroblasts (myofibroblasts generate large contractions and actively produce extracellular matrix (ECM) proteins to facilitate wound closure)
Rapid normalization of cell-to-cell communication (signaling) to improve cell function:
Angiogenesis
Angio = vessel
Genesis = generating / developing
Angiogenesis is the physiological process through which new blood vessels form, out of pre-existing vessels. For example: stretch marks